Elucidation of Primary Structure Elements Controlling Early Amyloid β-Protein Oligomerization
نویسندگان
چکیده
منابع مشابه
Elucidation of Primary Structure Elements Controlling Early Amyloid -Protein Oligomerization*□S
Assembly of monomeric amyloid -protein (A ) into oligomeric structures is an important pathogenetic feature of Alzheimer’s disease. The oligomer size distributions of aggregate-free, low molecular weight A 40 and A 42 can be assessed quantitatively using the technique of photo-induced cross-linking of unmodified proteins. This approach revealed that low molecular weight A 40 is a mixture of mon...
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Oligomers of amyloid beta-protein (Abeta) play a central role in the pathology of Alzheimer's disease. Of the two predominant Abeta alloforms, Abeta(1-40) and Abeta(1-42), Abeta(1-42) is more strongly implicated in the disease. We elucidated the structural characteristics of oligomers of Abeta(1-40) and Abeta(1-42) and their Arctic mutants, [E22G]Abeta(1-40) and [E22G]Abeta(1-42). We simulated ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m300825200